The Cardinals need a victory to make the playoffs for the first time since 2015, so it would greatly behoove them to have their star quarterback leading the way.
Murray injured his lower leg on the final pass of Saturday's 20-12 loss to the 49ers. He walked slowly to the bench after the play, but did not have a pronounced limp as he headed to the locker room following the final horn.
Kingsbury is "hopeful" Murray will be ready to go against Los Angeles.
"We'll see how he feels," the Cardinals coach said. "We're not going to put him out there if he can't play at a high level and doesn't feel safe to play. But we'll just have to see how he progresses."
Chris Streveler is "definitely" still the Cardinals' backup quarterback, Kingsbury said, with Brett Hundley remaining the third-stringer. Asked on 98.7, Arizona Sports Station, if Streveler or the more-experienced Hundley would start if Murray can't play, Kingsbury said "we'll cross that bridge if that comes up. We'll see, organizationally, who would be a better fit at that time."
Murray had limited mobility in the regular season finale last year in Los Angeles because of a hamstring issue. He stayed in the pocket all day and finished 26-of-42 passing for 325 yards with two touchdowns and two interceptions.
Kingsbury is confident Murray, the NFL's yards-per-carry leader at 6.2, can replicate that play-style if his mobility is limited by the leg injury.
"If that's how he's got to play, if he has to adjust his style, he can definitely play from the pocket and try to lead us in that way," Kingsbury said.
The Rams are dealing with an injury issue of their own at quarterback, as quarterback Jared Goff broke and dislocated his thumb in Week 16 against the Seahawks.
Kingsbury believes Goff will do everything in his power to play -- and there are national reports that the Rams’ starter is lobbying hard to put off surgery -- but the injury to his throwing hand could make it tough. (Update: Goff had surgery on the thumb and will not play against the Cardinals.)
Los Angeles' backup is John Wolford, who played collegiately at Wake Forest and went undrafted in 2018. He signed with the Jets but was waived after training camp that year. Wolford got his chance with the Rams after playing well in the Alliance of American Football League for the Arizona Hotshots in 2019.
Wolford was 130-of-206 for 1,617 passing yards with 14 touchdowns and seven interceptions before the league disbanded.
There was no preseason this year, but Wolford played well in four exhibition contests for Los Angeles in 2019. He threw for 249 yards with three touchdowns, zero interceptions and a passer rating of 95.7. His completion percentage was 56.8.
It is a big leap from the AAF and preseason football to a regular season contest, but Kingsbury is not taking Wolford lightly, especially knowing coach Sean McVay is guiding him.
Kingsbury said the Cardinals will prepare for Wolford "as best (they) can" by watching his AAF and college tape.
"He's a guy who can move around, make plays with his feet," Kingsbury said. "I'm sure if he is the guy, Sean will have him well-coached and operating at a high level. We'll have to be ready for everything."
EDMONDS 'DAY-TO-DAY' WITH HIP INJURY
Running back Chase Edmonds is day-to-day after leaving Saturday's loss to the 49ers with a hip injury, Kingsbury said. Edmonds is averaging 4.8 yards per carry and has 51 catches for 374 yards and four touchdowns.
"I'm not sure how that's going to play out, but we'll get him out there on Wednesday and see what all he can do," Kingsbury said.
Outside linebacker Dennis Gardeck's season is over, but Kingsbury declined to specify if it was a torn ACL that he suffered against the Eagles.
"I'm not going to get in the weeds on that deal," Kingsbury said.
Images from the Week 16 home finale against San Francisco at State Farm Stadium.