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- First overall selection in the 2019 NFL Draft, becoming the first player taken by the Cardinals with the No. 1 overall pick since 1958 (King Hill - Rice).
- Selected No. 9 overall by the Oakland Athletics in the 2018 MLB Draft, becoming the first person ever selected in the first round of both the NFL and MLB drafts.
- Earned 2019 AP NFL Offensive Rookie of the Year honors after becoming just the sixth QB in NFL history - and second rookie (Cam Newton) - with at least 3,500 passing yards and 500 rushing yards in a season. Became the third player in Cardinals history to earn NFL Offensive Rookie of the Year honors, joining Ottis Anderson (1979) and Anquan Boldin (2003).
- Named a Pro Bowl alternate and selected to the PFWA All-Rookie team after establishing franchise rookie records for passing yards (3,772), TD passes (20), completions (349), pass attempts (542), completion percentage (64.4), 300-yard games (five) and games with multiple TD passes (eight). Broke a 68-year-old single-season franchise record for rushing yards by a QB set by Charley Trippi (501) in 1951.
- Established an NFL rookie record by attempting 211 passes without throwing an INT between Games 4-10.
- Only rookie QB in the NFL to start all 16 games in 2019, becoming the first rookie QB in franchise history to accomplish that feat. Became the first rookie QB to start a season-opener for the Cardinals since Lamar McHan in 1954.
- Joined Newton (2011) as the only players in NFL history to throw for 300+ yards in each of his first two career games and became one of just three rookies in NFL history to post at least five 300-yard passing performances – Andrew Luck (6 in 2012) and Daniel Jones (5 in 2019).
- A first-team All-American as a junior in 2018 at Oklahoma, won the Heisman Trophy, was named the Associated Press Player of the Year and earned Davey O'Brien Quarterback of the Year, Manning Award and Earl Campbell Tyler Award honors.
- As a junior at Oklahoma in 2018, became the first FBS player ever to average at least 300 passing yards (311.5) and at least 70 rushing yards (71.5) per game for a full season.
- Posted a 57-3 record in 60 starts at QB in high school and college, including a perfect 43-0 record at national powerhouse Allen (TX) High School.