The 'Hail Murray' captured Best Play honors at the ESPYs on Saturday evening, defeating D.K. Metcalf's chasedown of Budda Baker, a goal by Marshall's Jamil Roberts to win the men's college soccer title and Simone Biles' unprecedented vault.
Hopkins attended the ceremony in New York City and accepted the award.
"This is such an honor," Hopkins said on the broadcast, which was televised nationally on ABC. "Great nominees up for this award, as well. First of all, I want to thank the state of Arizona for accepting me coming from Houston. Got to give it up for Arizona. I want to thank (GM) Steve Keim for allowing me to go out there and do what I do."
The play was only witnessed by 4,200 fans because of the pandemic but has been played on an endless loop ever since. The Cardinals trailed 30-26 with 11 seconds left in regulation when Murray spun to his left and threw across his body to Hopkins, who out-leaped three Bills defenders in the end zone for the 43-yard touchdown.
Hopkins summed it up well postgame, saying Buffalo was in good position but "it was a better catch by I."
The Cardinals won the game, 32-30, to improve to 6-3 on the season. It was the first go-ahead Hail Mary in a regular season since Aaron Rodgers found Richard Rodgers for a 61-yard game-winning touchdown against the Lions in 2015.
The 'Hail Murray' won Play of the Year at NFL Honors and now adds the multi-sport award.