History: San Francisco 49ers at Arizona Cardinals
- All Time Record: The Cardinals are 26-31 against the 49ers in the regular season.
- Interesting Fact: Kyler Murray (twice) and Drew Brees were the only quarterbacks to post a 100+ passer rating against the 49ers last season, and his 130.7 passer rating in Week 9 is the highest by a Cardinals quarterback in 57 meetings against San Francisco.
- Streaks: The Cardinals have won eight of the last 10 meetings.
- 2019 Results: The 49ers won both meetings in 2019. They defeated the Cardinals at State Farm Stadium 28-25 on Thursday Night Football (October 31). On November 17, the 49ers beat the Cardinals 36-26 at Levi's Stadium.
Players and Coaches to Know
San Francisco 49ers
- Head Coach Kyle Shanahan
- Quarterback Jimmy Garoppolo
- Position Players George Kittle, Richard Sherman
- Key Rookies Javon Kinlaw, Charlie Woerner
Arizona Cardinals
- Head Coach Kliff Kingsbury
- Quarterback Kyler Murray
- Position Players DeAndre Hopkins, Larry Fitzgerald
- Rookies Isaiah Simmons, Eno Benjamin
